Parazoxanide

Description

Anti-protozoal Agent for Treatment of Diarrhea                                                                                                            


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parazoxanide is

Tools & Services

Form

Hard Gelatin Capsules

Composition

Each hard gelatin capsule contains:

Active ingredient:

Nitazoxanide                                     500mg

Inactive ingredients:

Magnesium stearate and talc.

Properties

Pharmacological Actions:

The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate: ferredoxin oxidoreductase (PFOR) enzyme – dependent electron transfer reaction which is essential to anaerobic energy metabolism.

Studies have shown that the PFOR enzyme from Giardia lamblia directly reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. The DNA derived PFOR protein sequence of Cryptosporidium parvum appears to be similar to that of Giardia lamblia. Interference with the PFOR enzyme dependent electron transfer reaction may not be the only pathway by which nitazoxanide exhibits antiprotozoal activity.

Indications

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum.

Dosage

Treatment of diarrhea caused by Giardia lamblia or Cryptosporidium parvum for patients ≥ 12 years take 1 capsule 500mg every 12 hours with food for 3 days .

Storage

Store at temperature not exceeding 30°C in a dry place.

Keep out of reach of children

Package

Carton box containing 1, 2, 3 or 10 strips each of 6 hard gelatin capsule with insert leaflet.

Details

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